![]() These three drugs earned, respectively, $839m - up 23% year-on-year - $451m - up 33% year-on-year - and $63m - up 923% yoy - in 2022. Seagen markets and sells ADCETRIS, approved to treat Hodgkin's Lymphoma and T-cell Lymphoma, PADCEV, approved for Urothelial (bladder) cancer, and TIVDAK, approved for Cervical Cancer. The best known ADC drug developer - responsible for four of 12 ADCs approved for commercial use to date by the FDA - is Seattle based Seagen - formerly known as Seattle Genetics. These targeted agents combine the unique and very sensitive targeting capabilities of antibodies allowing sensitive discrimination between healthy and cancer tissues with the cell-killing ability of cytotoxic drugs. Mersana is a specialist in a specific field of drug development - antibody drug conjugates ("ADCs") - described as follows by :Īntibody-drug conjugates or ADCs are a new class of highly potent biopharmaceutical drug composed of an antibody linked, via a chemical linker, to a biologically active drug or cytotoxic compound. Mersana - An ADC Pioneer That Just Had Its Wings Clipped To explain why Mersana has been on such a roller-coaster ride and speculate about what direction it may move in next, it's necessary to take a step backward and study the path that the company - which enjoyed a >$1bn market cap valuation prior to today's sell-off - has been pursuing. Shares took flight at the beginning of May - rising from $3.7, to >$8 per share in less than one week. It may interest investors to know however that Mersana stock was trading at lower value less than two months ago. No cash balance or cash flow is included in the calculation.Mersana Therapeutics ( NASDAQ: MRSN) shares are in freefall - the stock price is down 58% today (at the time of writing), trading at a price of ~$4, owing to a partial clinical hold pausing new patient enrollment in the company's UP-NEXT and UPGRADE-A clinical trials of lead asset upifitamab rilsodotin in platinum-sensitive ovarian cancer. Please note all regulatory considerations regarding the presentation of fees must be taken into account. Backtested results are adjusted to reflect the reinvestment of dividends and other income and, except where otherwise indicated, are presented gross-of fees and do not include the effect of backtested transaction costs, management fees, performance fees or expenses, if applicable. Actual performance may differ significantly from backtested performance. Further, backtesting allows the security selection methodology to be adjusted until past returns are maximized. Since trades have not actually been executed, results may have under- or over-compensated for the impact, if any, of certain market factors, such as lack of liquidity, and may not reflect the impact that certain economic or market factors may have had on the decision-making process. Specifically, backtested results do not reflect actual trading or the effect of material economic and market factors on the decision-making process. ![]() Backtested performance is developed with the benefit of hindsight and has inherent limitations. This information is provided for illustrative purposes only. No representations and warranties are made as to the reasonableness of the assumptions. ![]() Certain assumptions have been made for modeling purposes and are unlikely to be realized. Changes in these assumptions may have a material impact on the backtested returns presented. General assumptions include: XYZ firm would have been able to purchase the securities recommended by the model and the markets were sufficiently liquid to permit all trading. Backtested results are calculated by the retroactive application of a model constructed on the basis of historical data and based on assumptions integral to the model which may or may not be testable and are subject to losses. The results reflect performance of a strategy not historically offered to investors and does not represent returns that any investor actually attained. Backtested performance is not an indicator of future actual results. Disclaimer: The TipRanks Smart Score performance is based on backtested results. ![]()
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![]() ![]() ![]() In some cases, the nature of the item means that it is non-returnable, for example, due to hygiene/health and personal care/wellness/consumable nature of the product. Office Products and Wireless Returns Policy 3 years ago 0 Comments Target Black Friday is LIVE Get deals like this Get the Baby Alive Super Snacks Snackin’ Sara for just 19. US 168.00 Realistic baby dolls don’t get more real than this The Baby Alive Snackin’ Sara can eat, drink, sleep, and poop. All audio, visual and textual content on this site (including all names, characters, images, trademarks and logos) are protected. New electronic items fulfilled by Amazon AU can be returned for change of mind, for a replacement or a full refund of the purchase cost of the item within 30 days of receipt of delivery.For information about returning faulty electronics please see Returning Faulty Items. Please see our Amazon Global Store Returns policy and Refunds policy for more information about returning Amazon Global Store items.Ĭamera, Electronics and PC Returns Policy Please see About Marketplace Returns & Refunds for details on Seller returns policies. Baby Alive Super Snacks Snackin' Sara - Blonde Hair (4.3) 101 reviews 125. To return faulty items see our Returning Faulty Items policy.įor items ordered on from a seller that fulfils and ships its own inventory (also called a third party seller), any returns will be in accordance with the returns policy set by that seller (not the Amazon AU returns policies). This change of mind return policy is in addition to, and does not affect your rights under the Australian Consumer Law including any rights you may have in respect of faulty items. Unless otherwise stated, original shipping fees for change of mind returns are not refunded. Please Contact Us and see About Items That Can’t Be Returned. In some circumstances, these items may be eligible for a refund or a replacement (for example, if you receive the wrong item due to an Amazon AU error or if the item is faulty). In some cases, the nature of the item means that it is non-returnable, for example, due to hygiene/health and personal care/wellness/consumable nature of the product. With Baby Alive Super Snacks Snackin’ Sara doll, experience the joy of being a mommy by making pretend yummy treats to feed her. ![]() You can return most new, unopened items fulfilled by Amazon AU within 30 days of receipt of delivery for a replacement or full refund of the price you paid for the item if you change your mind - see About Replacements and About Refunds. ![]() ![]() ![]() If you were to say, “in this company we will only use open-source software”, it will be difficult to hire a talented designer or a contractor because they use the software that makes them employable, which are Adobe products.Īlso, I have no doubt that you have more experience than I do when it comes to working in this industry. Whether we like it or not, Photoshop and Illustrator are graphics standards. Or, if they’re an SMB, they’ll outsource marketing and graphics but need to be able to view. From a business perspective, it’s not a matter of money, it’s a matter of what is an “industry standard”.įor example, if you work for a company that does manufacturing, they will have a Marketing department and will included a graphics person. I’ve haven’t dealt with their licensing in a couple of years so I don’t know if or how it’s changed. Anything less than that you had to deal with the situation you described. No question, Adobe products used to be a nightmare unless you had 200 licenses of the full suite. I hear ya’ and had to deal with that nightmare like you did. Especially if you are not the decision maker and you are not the owner of the company. Adobe is the standard for graphics, whether we like it or not.Īt some point, you need to consider whether this is something you need to battle with when it comes to your users. Getting graphics users to move on to a different product, especially when they need to work with other companies, will never happen. In my last positions we were able to get away with Photoshop Elements (which is still stand alone) as well as MS Photo Editor for many users. You will always have to argue with users that think they need to have Photoshop to edit pictures. ![]() So, test everything and work with the managers of those departments. The first one that comes to mind is scaling. When you are using AutoCAD or ARCGIS products, there can be some weird things when it comes to converting to. So just a heads up when it comes to freeware or using non-Adobe products. Once you're used to using all the known Adobe Shortcuts and Modes it's really hard to work with much else.īut I don't think Adobe have quite the same monopoly anymore when it comes to PDF Editors. I tried IrfanView which was a free alternative but it was horrible. Things like E-Sigs are free on PDF X-Change etc.Īs for Photoshop, I'm the only 'user (I'm one as well!)' with a License and I haven't found an alternative that stands up at all. I would try to get a list of exactly what functions everyone needs and seeing which PDF apps can/can't perform those actions. I'm sure there are more expensive options but we only need a few users to get on this. Buy a License for v14.that key is only valid for v14. The only thing to be wary of is that your license is for the version of the software at that moment in time. Bit more expensive than PDFXCE but it also uses forever licenses not cloud based ones. Nitro Pro - We have a few users with this.It also has free measurement tools etc that users have been taught on drawings. The key difference is that it's not a cloud based license, it's a one off fee that's about a 1/4 of the price of an Annual License of Acrobat if my recollection serves. Some of the functions you can get away without paying for but a handful of our users we had no choice but to pay it. PDF X-Change Editor ( ) - This is a much much cheaper alternative.PDF SAM - The free version of this allows page extraction, merging PDFs etc without watermarks.It includes a lot of professional and personalized functions that you may like.We use a couple of open source/free/cheaper PDF applications: This is an awesome PDF editor for both Windows and Mac. Among the plenty of alternatives, you may want to have a try of PDFelement. Some of them are for Mac, for Windows, or for both. To sum up, this article provides you 15 Adobe Acrobat alternative that can help you easily do the work process as you wish. The design of the software is simplistic and riddled with advertisements for other software.The user support links are often broken and provide inconsistent support.File conversion of files of different formats is just as simple with no reduction in quality with PrimoPDF.It gives users the capability to password-protect files and designs definite particulars to edit files precisely.Being free makes this software doubly popular for people to choose this as the ultimate PDF creation application. The PDF creation tool is rather quick and easy with the drag and drops feature that creates perfectly standardized PDF documents. PrimoPDF is a PDF building application that works smoothly with the Windows operating system. ![]() ![]() ![]() The effect grants a 20% chance of selecting a task of your choice. They also stack with the passive effect of the Slayer Master Cape. Each Slayer VIP Coupon offers 1 to 7 Slayer task re-roll chances. In simpler words, it doubles the chances of getting a good Slayer task. When a Slayer task is received, you will have the ability to select a second alternative with the help of these Coupons. These coupons are consumable items that are important for high-level Slayer. You can also farm Harmonic Dust by playing the harps located in the Ithell District (Prifddinas) however, it takes too long, so most players prefer purchasing it from the merchant itself. The item is used to create Crystal tools, such as Crystal Hatchet, Crystal Mattock, and Crystal Pickaxe. Harmonic Dust isn’t important for the progression in the game, but it’s still worth purchasing from the merchant. All these items require an Incomplete Hydrix. In terms of Ironman accounts, you can purchase and redeem the item for points, as it has many uses for end-game content, such as Reaper Necklace, Ring of Death, Amulet of Souls. You can simply click the purchase button for an effective and instant profit of 3M GP. These points are available for just 1.25M GP from the Travelling Merchant store. Alternatively, you can sell the Gift of the Reaper for around 4 to 4.3M GP. When you redeem the gift, you are awarded 20 Reaper Points, which can be used to purchase an Incomplete Hydrix (300 Reaper Points). Speaking of profit, there is no better item than purchasing Gift of the Reaper from the Travelling Merchant. Every time you redeem a Dragonkin Lamp, there’s a 1/100 chance to obtain the Effy Pet, but before that, you must complete the mini-quest called ‘Rebuilding Edgeville.’ The reason why Dragonkin Lamps are appealing is that it’s the only way to unlock one of the most prestigious pets on RuneScape. However, the awarded EXP is based on the skill level that you’re currently at, which means if you’re at level 99, you will be granted 48,000 EXP, and if you’re at level 60, you’ll be granted 10,740 EXP. It’s an EXP lamp that costs about 250,000 GP, and there are no real requirements to use it. Regardless of whatever stage or level you’re currently at, purchasing Dragonkin Lamps from the Travelling Merchant is always worth it. The best use of it would be on Big Chinchompas, Guthixian Cache, Penguin Hide & Seek, Giant Oyster, Tears of Guthix, Effigy Incubator, Sinkholes, and Herby Werby. For instance, a weekly D&D Token enables you to complete the limited Rush of Blood Slayer D&D twice in one week. They are a great source to progress ahead in the game without investing much time and money.ĭ&D Tokens allow you to have a Distraction and Diversion of choice that can be reset at will. Some of the D&Ds are done daily, such as Goebie Supply Runs, while others are done on a monthly basis, such as the Giant Oyster. Alternatively, there’s a Deep-Sea Fishing Discord channel that you can join to know where the Travelling Merchant has spawned.ĭ&D is known as Distraction and Diversion, which primarily centers around a number of activities that can only be completed at times. For instance, you can join the Friend’s Chat for help, which can be done by opening the Community Tab interface and clicking Social. It can take a while to locate the RuneScape merchant, so it’s best to use the RuneScape community as a means to locate him. The only drawback is that the Travelling Merchant only spawns on certain worlds and at specific times. You will need a fishing level of 68 to access it, and you can grab a bite of the Admiral Pie to temporarily boost your stats. Alternatively, you can attune a Grace of the Elves Amulet to reach directly at the Hub. The Travelling Merchant is located at the Deep-Sea Fishing Hub, which can be accessed by speaking to Goomah, who can be found in the Fishing Guild that is north of Ardougne. The rest of the three slots change on a daily basis, and the best way to figure out the upcoming and current stock is through the official wiki. ![]() The first slot is always fixated as the Uncharted Island Map, which has its own uses and offers a minor chance of obtaining the Tavia’s Fishing Rod (an item worth billions), from the RuneScape. ![]() ![]() Traveling Merchant stocks four items daily for players to purchase. Daily Activities like Vis Wax are a great and reliable source of income for players however, the activities are beneficial for both main and Ironman accounts is the Travelling Merchant. Players who want to optimize their RuneScape accounts should consider the importance and role of Dailies. ![]() ![]() Click Uninstall.įor instructions on how to uninstall Avast with Avast Clear on Windows 7 and Windows 8, check out our Avast Support guide. Select the folder containing your Avast program files, and select the Avast Antivirus product you want to uninstall (the location and product are usually detected automatically). ![]()
![]() ![]() Solving a puzzle, or even figuring out what the puzzle wants from you, results in plenty of happy eureka moments, not just from feeling smart but from having resisted the urge to cheat by looking up the answers. Sound often comes into play, which I really love, like a distant clunking sound while turning a wheel in a cabin, or the hum of a wire that lets you know a current is running through it, or an underground train puzzle where sounds play at the track intersections and combine with one another to give you directions. Sometimes simple observation can get you a long way toward solving a puzzle, like noticing a locked rocketship is connected to a brick bunker by an electrical wire. There's still a lot to enjoy, though, and plenty of clever puzzle design. There's a bit of story and lore told through books, notes, and holograms (originally they were cheesy FMV, now they're cheesy CG) but Myst is mostly built from puzzles, not stories. To gather the missing pages of the book and discover the story of the island and the family who once inhabited it, players need to solve elaborate puzzles that transport them to new islands, where they complete even more puzzles in order to return. In case you haven't had a chance to play one of the many versions of Myst in the past 28 years, the adventure game begins with you trapped on a strange island after reading a strange book. ![]() Myst, no matter how it looks in 2021, feels pretty outdated. Cyan Worlds say it's a "reimagined" Myst, but while it's far more modern-looking it's still almost exactly the same game. As a remake, Myst is a faithful one, but maybe a bit too faithful. And this new 3D Myst works on both desktop and in VR, so I got to spend time actually (virtually) walking around in it. ![]() Cyan Worlds has completely remade the game (again, following 2000's realMyst and 2014's realMyst: Masterpiece Edition, neither of which I played). It's a little weird to be back in Myst in 2021, after all this time. ![]() ![]() ![]() However, there are times when using shortening is appropriate. Although you could easily substitute some of the butter for shortening, your frosting will have a greasy mouthfeel and taste to it. Stabilizing the frosting is often the primary reason why white buttercream frosting recipes call for shortening or a mixture of shortening and butter. The bright white frosting they use is often not made with real butter and instead is made from shortening which allows cakes to be left out for long periods of time. When you walk pass the bakery section at your local store you often see beautiful decorated cakes in bakery case. Is Homemade Frosting the Same as Grocery Store Bakery Frosting? Most boutique cupcake shops use a base buttercream frosting like this one and add different flavors to it to create endless buttercream recipe combinations– much like how most ice cream flavors start with a vanilla ice cream base. However, for all other occasion cakes including birthdays, This classic vanilla buttercream frosting recipe is the gold standard. These frostings are slightly less sweet but require you to cook sugar into a syrup while whipping eggs and butter at a high speed as it magically whips into the most luxurious buttercream – which is why it is the best wedding cake frosting of choice for brides. Most wedding cake frosting recipes are egg-based such as Italian, Swiss, or French. Keep in mind, not all frosting recipes are alike. With so many buttercream icing recipes to choose from, this truly is the best frosting. Whether you’re frosting cupcakes for a child’s class party, need the best birthday cake frosting for icing, or want a stiff enough buttercream frosting to handle your decorative piping work for cake decorating, this buttercream recipe will do everything you need for your cake and cupcake frosting needs.įrankly, it’s the best buttercream frosting recipe because it is so versatile, adaptable, and easy to make. Trust me when I say you want to have a go-to reliable best buttercream frosting recipe you can always count on. You should not attempt to stiffen store-bought frosting.Īs a former professional wedding cake decorator, I’ve been using this buttercream recipe for over 25 years. ![]() If you don’t believe me, try piping frosting on a cupcake using frosting in a tub. The best buttercream frosting is the one that works with you for whatever you need it to do versus being limited by what it can do (cough. It should definitely not taste greasy, artificial, or overly sweet. This is why it’s called buttercream frosting. The frosting should taste light, airy, and like sweetened whipped butter. The buttercream frosting is made by creaming butter with powdered sugar, vanilla, salt, and a little bit of heavy cream, then whipping it into the perfect buttercream frosting.
![]() ![]() Click on the image, then look to the upper right corner and click on the menu button (three vertical dots). Then open your gallery/photos app and from there open the “download” folder, where you will see the image you just downloaded. Now you will able to crop or arrange the image to your liking when it looks perfect, tap “set.” The only thing left to do is select whether you want the image to be your lock screen, home screen or both.and enjoy! Android: Choose one of our many exquisite wallpapers and download it by clicking on the yellow “download” button just below the image. Use the “share” button (looks like an arrow curving out of a box) and then select the “use as a wallpaper” button. Next choose “save image” from the options below, go to your Photos and find the image you just downloaded. ![]() Then tap on the image and hold for a few seconds. Now go back to your desktop and admire your new wallpaper! iPhone/iPad: Select a beautiful wallpaper and click the yellow download button below the image. On your computer, find the downloaded image and click on the photo. Then click Apple Menu > System Preferences > Desktop & Screen Saver > Desktop. ![]() Find the image on your computer, right-click it and then click “set as desktop background.” Now the only thing left to do is enjoy your new wallpaper! Mac: Find a wallpaper you love and click the blue “download” button just below. When you click the “download” button, the wallpaper image will be saved, most likely in your “downloads” folder. Just below the image you’ll see a button that says “Download.” You will also see your screen’s resolution, which we have figured out for you. ![]() ![]() ![]() The two teams have met each other 127 times (including 2 postseason games), with the New England Patriots winning 77 games and the Buffalo Bills winning 49 games. 1st) (Shotgun) PENALTY on SEA-P.Haynes, False Start, 5 yards, enforced at DEN 46 - No. ![]() Seattle Seahawks NFL game from Septemon ESPN. The league threatened last week that protocol violations requiring schedule adjustment could result in game forfeitures.įor now, the Titans have avoided a Week 5 forfeiture. The following is a list of all regular season and postseason games played between the New England Patriots and Buffalo Bills. Play-by-play action for the Denver Broncos vs. Yahoo Sports’ Charles Robinson reported this week the that the NFL is likely to punish the Titans for violating protocol. 30 in violation of the NFL’s COVID-19 protocol. Several Titans players reportedly held an informal, unsanctioned off-site workout on Sept. Whether the game is at Empower Field at Mile High or Gillette Stadium, theres nothing like being there in person for a New England Patriots vs. Titans facilities have been closed since Sept. The Titans reportedly recorded two more positive tests on Thursday. The Titans had their Week 3 matchup against the Pittsburgh Steelers postponed after an outbreak of 21 COVID-19 cases among players and team staff. Monday’s game will be played in New England. Newton will obviously be the starter if he’s medically cleared and physically ready. The first-year Patriots quarterback posted a Twitter message on Wednesday urging COVID-19 safety, while head coach Bill Belichick vowed earlier this week to “see how it goes” with the team’s quarterback situation for Week 5. ![]() Newton’s status for Monday remains unclear. The league announced on Thursday that the Bills, Titans, and Jaguars will all be the designated home teams for games in London. Game coverage will feature Al Michaels and Kirk Herbstreit, and reporter Kaylee. Published Janu02:14 AM 0 seconds of 0 secondsVolume 0 The NFL will be playing five games in Europe next season and we know five of the teams that will be playing in those contests. The Patriots will have a second straight Sunday game moved to Monday. Prime nfl announcers Amazon Prime Video play-by-play announcer Al. ![]() ![]() Pay special attention to any inside surfaces – you may need to angle the gun to completely spray those hard-to-reach areas. TC Pro tips are compatible with the TC Pro Tip Guard. Reverse the SwitchTip to easily clear clogs. The 312 TC Pro SwitchTip has a 0.012 inch orifice and produces a 6 to 8 inch fan. Make repeated passes following the boards, overlapping each pass by 50%. The Reverse-A-Clean (RAC) 312 TC Pro SwitchTip is designed for narrower surfaces and thinner materials like water-based lacquers, stains, and polyurethanes. /rebates/2fp2fGraco-Handheld-TC-Pro-Cordless-Airless-Paint-Sprayer-17N1662f301100278&. (A tip extension is a useful accessory, as it will allow you to spray the decking at the proper distance with needing to bend over.) Spray the outer edges first, “banding” the area that you will spray, and then spray any corners. For the decking, work in sections only as far as you can comfortably reach and follow the planks lengthwise, keeping the spray tip approximately 12 inches from the surface.Keep a brush handy in case you need to brush out any excess-sprayed stain. ![]() Ideal For Those Painting Up To 50 Gallons Per Year.
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